Moment analysis of drug disposition in kidney: transcellular transport kinetics of p-aminohippurate in the isolated perfused rat kidney.

@article{Hori1988MomentAO,
  title={Moment analysis of drug disposition in kidney: transcellular transport kinetics of p-aminohippurate in the isolated perfused rat kidney.},
  author={Ryohei Hori and Yusuke Tanigawara and Yoshihiro Saito and Yoichi Hayashi and Tetsuya Aiba and Kenzo Okumura and Akira Kamiya},
  journal={Journal of pharmaceutical sciences},
  year={1988},
  volume={77 6},
  pages={471-6}
}
The mean renal epithelial cell residence time, Tcell, was defined as a model-independent characteristic of the transcellular transport process in the isolated perfused kidney. The transcellular transport process includes transport at the basolateral membrane, diffusion in the cytosol, and transport at the brush border membrane. The parameter Tcell represents the mean time for the drug secreted from the tubules to pass through the renal epithelial cells, and is calculated as the difference of… CONTINUE READING

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