Molten globular characteristics of the native state of apomyoglobin

@article{Lin1994MoltenGC,
  title={Molten globular characteristics of the native state of apomyoglobin},
  author={Laura L Lin and Rachel J. Pinker and Kirk Forde and George D. Rose and Neville R. Kallenbach},
  journal={Nature Structural Biology},
  year={1994},
  volume={1},
  pages={447-452}
}
Apomyoglobin, myoglobin lacking the haem group, is a natural intermediate in biosynthesis of myoglobin, and has some structural features in common with the haem-containing native state. Unfolding or refolding studies of apomyoglobin have identified a molten globule intermediate at acid pH. We show here that both the native state of apomyoglobin and the molten globule intermediate have highly plastic structures. Substitution of single amino acids on the surface or in the interior of helices in… CONTINUE READING