Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives.

@article{Silva2005MolluscicidalAO,
  title={Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives.},
  author={Tania Maria Sarmento Silva and Celso de Amorim C{\^a}mara and Ticiano P Barbosa and Andre Soares and Luciana C da Cunha and Angelo Pinto and Maria Domingues Vargas},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 1},
  pages={193-6}
}
A series of new amino derivatives and a new partially hydrogenated derivative of the natural naphthoquinone lapachol were assayed for molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC(50) values, and a 3.1 microg/mL value for the most potent derivative of the series. The toxicity is in agreement with the decrease of polar character of the tested compounds.