• Corpus ID: 209181341

Molindone: a controlled evaluation in chronic schizophrenic patients.

  title={Molindone: a controlled evaluation in chronic schizophrenic patients.},
  author={Gallant Dm and Bishop Mp},
  journal={Current Therapeutic Research-clinical and Experimental},
  • Gallant Dm, Bishop Mp
  • Published 1 September 1968
  • Medicine
  • Current Therapeutic Research-clinical and Experimental
Revisiting loxapine: a systematic review
The available data suggests that the antipsychotic efficacy of loxapine is similar to the efficacy of other typical or atypical antipsychotics, with an adverse effects profile comparable to that of the typical antippsychotics at high doses for chronic treatment.
Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects
The primary QT analysis conclusion is that there is no apparent QT prolongation associated with the therapeutic dose of inhaled loxapine and the analyses of QTc outliers, and the lack of emergent diagnostic findings for QTtcI,QTcB, and QTTcF supported this conclusion.
Amoxapine: A Review of its Pharmacology and Efficacy in Depressed States
The antianxiety activity of this drug appears to be minimal, but further studies in suitably selected patients are required to determine its role in patients with anxiety associated with primary depression.
Antipsychotic Drugs: Clinical Pharmacology and Therapeutic Use
No specific treatment of the schizophrenias and other psychoses was available until Laborit’s discovery of chlorpromazine as the first antipsychotic agent, which has led to a marked reduction in the number of hospitalised shizophrenic patients.
Loxapine: A Review of its Pharmacological Properties and Therapeutic Efficacy as an Antipsychotic Agent
In the majority of longer-term trials in acute and chronic schizophrenia it has been significantly superior to a placebo, and about equieffective with chlorpromazine, haloperidol, trifluoperazine, and thiothixene, after 4 to 12 weeks of treatment (see table II).
Antipsychotic Pharmacotherapy and Orthostatic Hypotension
Nonpharmacological strategies and patient education, most notably, slowly rising from the supine position, are crucial first steps in the prevention and treatment of both symptomatic and asymptomatic orthostatic hypotension.
Clinical and plasma level characteristics of intramuscular and oral loxapine
Comparisons of the intramuscular and oral forms of loxapine succinate were compared in their clinical, side effect, and blood level characteristics in ten hospitalized chronic schizophrenic patients failed to indicate any clinical or side effect differences in the two forms.
Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors
  • J. Walters, R. Roth
  • Biology, Psychology
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
It was found that administration of the dopamine agonists, apomorphine or ET-495 [1-(2′-pyrimidyl)-piperonyl-piperazine], modified the apparent activity of striatal tyrosine hydroxylase when impulse flow was blocked in dopamine neurons.