Moleculo Long-Read Sequencing Facilitates Assembly and Genomic Binning from Complex Soil Metagenomes

@inproceedings{White2016MoleculoLS,
  title={Moleculo Long-Read Sequencing Facilitates Assembly and Genomic Binning from Complex Soil Metagenomes},
  author={Richard S A White and Eric M. Bottos and Taniya Roy Chowdhury and Jeremy D. Zucker and Colin J Brislawn and Carrie Diana Nicora and Sarah J Fansler and Kurt R. Glaesemann and Kevin Glass and Janet K. Jansson},
  booktitle={mSystems},
  year={2016}
}
Soil metagenomics has been touted as the "grand challenge" for metagenomics, as the high microbial diversity and spatial heterogeneity of soils make them unamenable to current assembly platforms. Here, we aimed to improve soil metagenomic sequence assembly by applying the Moleculo synthetic long-read sequencing technology. In total, we obtained 267 Gbp of raw sequence data from a native prairie soil; these data included 109.7 Gbp of short-read data (~100 bp) from the Joint Genome Institute (JGI… CONTINUE READING
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