Molecules and morphology: where's the homology?

  title={Molecules and morphology: where's the homology?},
  author={William J. Dickinson},
  journal={Trends in genetics : TIG},
  volume={11 4},

Deep homology: A view from systematics

  • R. Scotland
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2010
Four examples – three from plants and one from animals – demonstrate that homologous developmental mechanisms can regulate a range of morphological relations including analogy, homoplasy and examples of uncertain homology.

Developmental genetics and traditional homology.

  • J. BolkerR. Raff
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1996
It is argued that although developmental genetic data can help identify homologous structures, they are neither necessary nor sufficient, and do not in any case justify a new definition of homology.

Homology in Development and the Development of the Homology Concept1

Abstract Homology is a central concept for Developmental Evolution. Here I argue that homology should be explained within the reference processes of development and evolution; development because it

Typology now: homology and developmental constraints explain evolvability

This paper attempts to bridge the gap between developmental and phylogenetic approaches to homology and to show that developmental constraints and natural selection are compatible and in fact complementary.

Homoplasy and homology: dichotomy or continuum?

  • B. Hall
  • Biology
    Journal of human evolution
  • 2007

Molecular homology and multiple-sequence alignment: an analysis of concepts and practice

This work presents examples of molecular-data levels at which homology might be considered, and proposes terminology with which to better describe and discuss molecular homology at these levels, and sheds light on the multitude of automated procedures that have been created for multiple-sequence alignment.

The history of the homology concept and the “Phylogenetisches Symposium”

It is described briefly how a typological use of homology to designate organs and body parts in the same position anatomically in different organisms was changed by Darwin’s theory of evolution into a phylogenetic concept.



Homology in classical and molecular biology.

There are more kinds of homologous relation between molecular sequences than in morphology, and the terms paraxenology and plerology are proposed for two of these kinds--respectively, the consequence of multiple xenology and of gene conversion.

Distinguishing homologous from analogous proteins.

This work provides a means by which it is possible to determine whether two groups of related proteins have a common ancestor or are of independent origin, and how many nucleotide positions must differ in the genes encoding the two presumptively homologous proteins.

Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta.

A Drosophila gene, the T-related gene (Trg), with high similarity to T within a stretch of approximately 200 amino acids, the DNA-binding domain of T is identified, raising the question of a common evolutionary origin of the hindgut of insects and the notochord of chordates.

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.

A Drosophila transcription factor that binds to fat body-specific enhancers of alcohol dehydrogenase (Adh) and yolk protein genes and DNA sequence analysis of cDNA clones encoding this protein indicates that it is a member of the CREB/ATF family of transcriptional regulatory proteins.