Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis.

Abstract

PURPOSE The inhibitor of apoptosis proteins (IAP) are overexpressed in hormone-refractory prostate cancer, rendering the cancer cells resistant to radiation. This study aims to investigate the radiosensitizing effect of small-molecule IAP inhibitor both in vitro and in vivo in androgen-independent prostate cancer and the possible mechanism of… (More)
DOI: 10.1158/1078-0432.CCR-08-0188

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