Molecularly imprinted solid-phase extraction for the selective determination of bromhexine in human serum and urine with high performance liquid chromatography.

@article{Javanbakht2009MolecularlyIS,
  title={Molecularly imprinted solid-phase extraction for the selective determination of bromhexine in human serum and urine with high performance liquid chromatography.},
  author={Mehran Javanbakht and Mohammad Hadi Namjumanesh and B Akbari-Adergani},
  journal={Talanta},
  year={2009},
  volume={80 1},
  pages={133-8}
}
In this work, a novel method is described for the determination of bromhexine in biological fluids using molecularly imprinted solid-phase extraction as the sample cleanup technique combined with high performance liquid chromatography (HPLC). The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker, chloroform as porogen and bromhexine as the template molecule. The novel imprinted… CONTINUE READING
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