Molecularly imprinted polymers for the clean-up of a basic drug from environmental and biological samples.

@article{Chapuis2006MolecularlyIP,
  title={Molecularly imprinted polymers for the clean-up of a basic drug from environmental and biological samples.},
  author={Florence Chapuis and Jean Ulrich Mullot and V. Balabaud Pichon and Gilles Tuffal and Maj Duane R Hennion},
  journal={Journal of chromatography. A},
  year={2006},
  volume={1135 2},
  pages={
          127-34
        }
}
A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract an alpha-blocker, i.e. alfuzosin, from human plasma. The synthesis of the MIP was performed in dichloromethane with methacrylic acid as monomer and the target drug as template. A first series of experiments was carried out in dichloromethane to estimate the potential of the MIP in its specific recognition medium, i.e. dichloromethane, by developing a selective procedure and by measuring the capacity of… CONTINUE READING
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