Molecularly designed alginate hydrogels susceptible to local proteolysis as three-dimensional cellular microenvironments.

Abstract

The development of sophisticated three-dimensional (3-D) cell culture microenvironments that recreate some of the complexity of the natural extracellular matrix (ECM) remains a challenging task. Here, the modification of alginate through partial crosslinking with a matrix metalloproteinase (MMP) cleavable peptide (proline-valine-glycine-leucine-isoleucine… (More)
DOI: 10.1016/j.actbio.2010.12.029

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