Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.

@article{Akanuma2011MolecularweightdependentAT,
  title={Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.},
  author={Shin-ichi Akanuma and Yasuo Uchida and Sumio Ohtsuki and Jun-ichi Kamiie and Masanori Tachikawa and Tetsuya Terasaki and Ken-Ichi Hosoya},
  journal={Drug metabolism and pharmacokinetics},
  year={2011},
  volume={26 6},
  pages={602-11}
}
β-Lactam antibiotics have cerebral and peripheral adverse effects. Multidrug resistance-associated protein 4 (MRP4) has been reported to transport several β-lactam antibiotics, and its expression at the blood-brain barrier also serves to limit their distribution to the brain. Therefore, the purpose of this study was to clarify the structure-activity relationship of MRP4-mediated transport of β-lactam antibiotics using MRP4-expressing Sf9 membrane vesicles. The transport activity was evaluated… CONTINUE READING