Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-L-glutamate)nanoparticles.

  title={Molecular weight controls the elongation of oblate-shaped degradable poly(γ-benzyl-L-glutamate)nanoparticles.},
  author={Olivier Cauchois and Freimar Segura-S{\'a}nchez and Gilles Ponchel},
  journal={International journal of pharmaceutics},
  volume={452 1-2},
The shape of nanoparticles in drug targeting applications has been recently suggested as being an interesting parameter for modulating their fate in the body after delivery. In view of investigating the incidence of this parameter on in vivo distribution, poly(γ-benzyl-L-glutamate) (PBLG) has been selected for preparing non-spherical nanoparticles. PBLG is a degradable polymer forming α-helices rods, which can easily self-assemble by nanoprecipitation into oblate-shaped nanoparticles. Varying… CONTINUE READING

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