Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope.

@article{Mizuta2003MolecularVO,
  title={Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope.},
  author={Ryushin Mizuta and Kousuke Iwai and Masatsugu Shigeno and Midori Mizuta and Takeshi Uemura and Tatsuo Ushiki and Daisuke Kitamura},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={4431-4}
}
Immunoglobulin heavy-chain (IgH) class switch recombination (CSR) is initiated by DNA breakage in the switch (S) region featuring tandem repetitive nucleotide sequences. Various studies have demonstrated that S-region transcription and splicing proceed to genomic recombination and are indispensable for CSR in vivo, although the precise molecular mechanism is largely unknown. Here, we show the novel physical property of the in vitro transcribed S-region RNA by direct visualization using an… CONTINUE READING
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AFM Image of Immunoglobulin Switch Region RNA/DNA Complex 4434 by gest on N ovem er 13

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