Molecular tweezers and clips as synthetic receptors. Molecular recognition and dynamics in receptor-substrate complexes.

@article{Klrner2003MolecularTA,
  title={Molecular tweezers and clips as synthetic receptors. Molecular recognition and dynamics in receptor-substrate complexes.},
  author={F G Kl{\"a}rner and Bj{\"o}rn Kahlert},
  journal={Accounts of chemical research},
  year={2003},
  volume={36 12},
  pages={
          919-32
        }
}
The molecular tweezers (1, 2) and clips (3-7) containing naphthalene and benzene spacer units can be synthesized via repetitive Diels-Alder reactions by the use of a molecular "Lego" set consisting of bisdienophiles (8, 9, 14) and dienes (10, 13). The new receptors selectively bind electron-deficient neutral and cationic substrates in solution. Only the benzene-spaced tweezers form complexes with aliphatic substrates, whereas the other receptors bind aromatic substrates preferentially. HPLC… 
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TLDR
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