Molecular tools for the rapid detection of drug resistance in animal trypanosomes.

  title={Molecular tools for the rapid detection of drug resistance in animal trypanosomes.},
  author={Vincent Delespaux and D. M. Geysen and Peter Van den Bossche and Stanny Geerts},
  journal={Trends in parasitology},
  volume={24 5},
There are currently 17 African countries in which animal trypanocidal drug resistance has been reported. Large-scale surveys were carried out in only ten of them. The lack of baseline information is mainly due to the fact that the methods currently available for the detection of drug resistance are laborious, expensive and time consuming. In this review the mechanisms involved in resistance to isometamidium and diminazene will be discussed, together with some new molecular detection tools that… CONTINUE READING
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