Molecular time: an often overlooked dimension to cardiovascular disease.

@article{Martino2009MolecularTA,
  title={Molecular time: an often overlooked dimension to cardiovascular disease.},
  author={Tami A Martino and Michael Sole},
  journal={Circulation research},
  year={2009},
  volume={105 11},
  pages={
          1047-61
        }
}
Diurnal rhythms influence cardiovascular physiology such as heart rate and blood pressure and the incidence of adverse cardiac events such as heart attack and stroke. For example, shift workers and patients with sleep disturbances, such as obstructive sleep apnea, have an increased risk of heart attack, stroke, and sudden death. Diurnal variation is also evident at the molecular level, as gene expression in the heart and blood vessels is remarkably different in the day as compared to the night… CONTINUE READING

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