Molecular tension sensors report forces generated by single integrin molecules in living cells.

@article{Morimatsu2013MolecularTS,
  title={Molecular tension sensors report forces generated by single integrin molecules in living cells.},
  author={Masatoshi Morimatsu and Armen H. Mekhdjian and Arjun S. Adhikari and Alexander R Dunn},
  journal={Nano letters},
  year={2013},
  volume={13 9},
  pages={3985-9}
}
Living cells are exquisitely responsive to mechanical cues, yet how cells produce and detect mechanical force remains poorly understood due to a lack of methods that visualize cell-generated forces at the molecular scale. Here we describe Förster resonance energy transfer (FRET)-based molecular tension sensors that allow us to directly visualize cell-generated forces with single-molecule sensitivity. We apply these sensors to determine the distribution of forces generated by individual… CONTINUE READING
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