Molecular techniques for diagnosis of Clostridium difficile infection: systematic review and meta-analysis.

@article{OHoro2012MolecularTF,
  title={Molecular techniques for diagnosis of Clostridium difficile infection: systematic review and meta-analysis.},
  author={John C. O'Horo and Amy A Jones and Matthew Sternke and Christopher W Harper and Nasia Safdar},
  journal={Mayo Clinic proceedings},
  year={2012},
  volume={87 7},
  pages={643-51}
}
OBJECTIVE To assess the usefulness of 2 rapid molecular diagnostic techniques, polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP), in Clostridium difficile infection (CDI). METHODS We conducted a systematic review and meta-analysis to evaluate the accuracy of PCR and LAMP in diagnosis of CDI, including studies that used toxigenic culture or cytotoxicity assay as reference standard. RESULTS A search of PubMed and CinAHL medical databases yielded 25 PCR studies… CONTINUE READING
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