Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.

@article{Wang2000MolecularTO,
  title={Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.},
  author={Haiyan Wang and Peter A. Antinozzi and Kerstin A. Hagenfeldt and Pierre Maechler and Claes B Wollheim},
  journal={The EMBO journal},
  year={2000},
  volume={19 16},
  pages={4257-64}
}
The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1 alpha (HNF1 alpha)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3). Nuclear localized HNF1 alpha-P291fsinsC protein exerts its dominant-negative effects by competing with endogenous HNF1 alpha for the cognate DNA-binding site. HNF1 alpha controls multiple genes… CONTINUE READING
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