Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts.

@article{Patra2008MolecularTO,
  title={Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts.},
  author={S. K. Patra and Federica Rizzi and Antonia Siomara Rodrigues Silva and Dumitrița Olivia Rugină and Saverio Bettuzzi},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2008},
  volume={59 Suppl 9},
  pages={
          217-35
        }
}
Proteomic studies on anticancer activity of Green Tea Catechins (specifically EGCG) are suggesting a large set of protein targets that may directly interact with EGCG and alter the physiology of diseased cells, including cancer. Of notice, benign cells are usually left untouched. Lipid rafts have been recently recognized as signal processing hubs and suggested to be involved in drug uptake by means of endocytosis. These findings are suggesting new insights on the molecular mechanisms of… CONTINUE READING

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