Molecular targets for the myorelaxant action of diazepam.

@article{Crestani2001MolecularTF,
  title={Molecular targets for the myorelaxant action of diazepam.},
  author={Florence Crestani and Karin L{\"o}w and Ruth Keist and M Mandelli and Hanns M{\"o}hler and Uwe Rudolph},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 3},
  pages={442-5}
}
Diazepam is used clinically for its myorelaxant, anxiolytic, sedative, and anticonvulsant properties. Although the anxiolytic action is mediated by alpha2 gamma-aminobutyric acid A (GABA(A)) receptors, the sedative action and in part the anticonvulsant action are mediated by alpha1 GABA(A) receptors. To identify the GABA(A) receptor subtypes mediating the action of diazepam on muscle tone, we have assessed the myorelaxant properties of diazepam in alpha2(H101R) and alpha3(H126R) knock-in mice… CONTINUE READING

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