Molecular targets for design of novel inhibitors to circumvent aminoglycoside resistance.

@article{Jana2005MolecularTF,
  title={Molecular targets for design of novel inhibitors to circumvent aminoglycoside resistance.},
  author={Soumya Jana and Jahar Kanti Deb},
  journal={Current drug targets},
  year={2005},
  volume={6 3},
  pages={
          353-61
        }
}
Aminoglycosides are a class of clinically important antibiotics used in the treatment of infections caused by Gram-positive and Gram-negative organisms. They are bactericidal, targeting the bacterial ribosome, where they bind to the A-site and disrupt protein synthesis. Antibiotic resistance is a growing problem for all classes of anti-infective agents. One of the first groups of antibiotics to encounter the challenge of resistance was the aminoglycoside -aminocyclitol family. Initially, the… CONTINUE READING