Molecular targets and mechanisms for ethanol action in glycine receptors.

  title={Molecular targets and mechanisms for ethanol action in glycine receptors.},
  author={Daya I Perkins and James R. Trudell and Daniel K. Crawford and Ronald L. Alkana and Daryl L Davies},
  journal={Pharmacology & therapeutics},
  volume={127 1},
Glycine receptors (GlyRs) are recognized as the primary mediators of neuronal inhibition in the spinal cord, brain stem and higher brain regions known to be sensitive to ethanol. Building evidence supports the notion that ethanol acting on GlyRs causes at least a subset of its behavioral effects and may be involved in modulating ethanol intake. For over two decades, GlyRs have been studied at the molecular level as targets for ethanol action. Despite the advances in understanding the effects of… CONTINUE READING

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