Molecular targeting of acid ceramidase: implications to cancer therapy.

@article{Zeidan2008MolecularTO,
  title={Molecular targeting of acid ceramidase: implications to cancer therapy.},
  author={Youssef H. Zeidan and Russell William Jenkins and John B Korman and Xiang Liu and Lina M Obeid and James Scott Norris and Yusuf A. Hannun},
  journal={Current drug targets},
  year={2008},
  volume={9 8},
  pages={
          653-61
        }
}
Increasingly recognized as bioactive molecules, sphingolipids have been studied in a variety of disease models. The impact of sphingolipids on cancer research facilitated the entry of sphingolipid analogues and enzyme modulators into clinical trials. Owing to its ability to regulate two bioactive sphingolipids, ceramide and sphingosine-1-phosphate, acid… CONTINUE READING