Molecular targeted therapy for patients with melanoma: the promise of MAPK pathway inhibition and beyond.

@article{Sullivan2010MolecularTT,
  title={Molecular targeted therapy for patients with melanoma: the promise of MAPK pathway inhibition and beyond.},
  author={Ryan J. Sullivan and Michael B. Atkins},
  journal={Expert opinion on investigational drugs},
  year={2010},
  volume={19 10},
  pages={1205-16}
}
IMPORTANCE OF THE FIELD Recent discoveries have expanded the understanding of the molecular signaling events critical to melanomagenesis and led to the development of targeted therapeutic agents that are revolutionizing the treatment of patients with advanced melanoma. AREAS COVERED IN THIS REVIEW This article reviews current therapy and its limitations, describes the key pathogenic mechanisms in melanoma for which inhibitors have been tested, and summarizes the results of clinical trials… CONTINUE READING

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