Molecular subtyping for clinically defined breast cancer subgroups

  title={Molecular subtyping for clinically defined breast cancer subgroups},
  author={Xi W Zhao and Einar Andreas R\odland and Robert Tibshirani and Sylvia K Plevritis},
  booktitle={Breast Cancer Research},
Breast cancer is commonly classified into intrinsic molecular subtypes. Standard gene centering is routinely done prior to molecular subtyping, but it can produce inaccurate classifications when the distribution of clinicopathological characteristics in the study cohort differs from that of the training cohort used to derive the classifier. We propose a subgroup-specific gene-centering method to perform molecular subtyping on a study cohort that has a skewed distribution of clinicopathological… CONTINUE READING
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