Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.

@article{Scott2011MolecularSO,
  title={Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.},
  author={Milcah C Scott and Aaron L. Sarver and Katherine J Gavin and Venugopal Thayanithy and David M. Getzy and Robert A. Newman and Gary R. Cutter and Kerstin Lindblad-Toh and William C. Kisseberth and Lawrence E. Hunter and Subbaya Subramanian and Matthew Breen and Jaime F Modiano},
  journal={Bone},
  year={2011},
  volume={49 3},
  pages={356-67}
}
The heterogeneous and chaotic nature of osteosarcoma has confounded accurate molecular classification, prognosis, and prediction for this tumor. The occurrence of spontaneous osteosarcoma is largely confined to humans and dogs. While the clinical features are remarkably similar in both species, the organization of dogs into defined breeds provides a more homogeneous genetic background that may increase the likelihood to uncover molecular subtypes for this complex disease. We thus hypothesized… CONTINUE READING

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