Molecular studies on an ancient gene encoding for carbamoyl-phosphate synthetase.

@article{Schofield1993MolecularSO,
  title={Molecular studies on an ancient gene encoding for carbamoyl-phosphate synthetase.},
  author={James P R Schofield},
  journal={Clinical science},
  year={1993},
  volume={84 2},
  pages={119-28}
}
1. Carbamoyl-phosphate synthetase (EC 6.3.5.5.) catalyses the synthesis of carbamoyl phosphate, the immediate precursor of arginine and pyrimidine biosynthesis, and is highly conserved throughout evolution. The large subunit of all carbamoyl-phosphate synthetases sequenced to date comprises two highly homologous halves, the product of a proposed ancestral gene duplication. The sequences of the enzymes of Escherichia coli, Drosophila melanogaster, Saccharomyces cerevisiae, rat and Syrian hamster… CONTINUE READING

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