Molecular studies on an ancient gene encoding for carbamoyl-phosphate synthetase.

  title={Molecular studies on an ancient gene encoding for carbamoyl-phosphate synthetase.},
  author={James P R Schofield},
  journal={Clinical science},
  volume={84 2},
1. Carbamoyl-phosphate synthetase (EC catalyses the synthesis of carbamoyl phosphate, the immediate precursor of arginine and pyrimidine biosynthesis, and is highly conserved throughout evolution. The large subunit of all carbamoyl-phosphate synthetases sequenced to date comprises two highly homologous halves, the product of a proposed ancestral gene duplication. The sequences of the enzymes of Escherichia coli, Drosophila melanogaster, Saccharomyces cerevisiae, rat and Syrian hamster… CONTINUE READING


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