Molecular studies of knockdown resistance to pyrethroids: cloning of domain II sodium channel gene sequences from insects†

@inproceedings{MartnezTorres1997MolecularSO,
  title={Molecular studies of knockdown resistance to pyrethroids: cloning of domain II sodium channel gene sequences from insects†},
  author={David Mart{\'i}nez-Torres and Alan L. Devonshire and Martin S Williamson},
  year={1997}
}
Knockdown resistance (kdr) is a target-site resistance mechanism that confers nerve insensitivity to DDT and pyrethroid insecticides. In the housefly, Musca domestica, molecular cloning of the para-type sodium channel gene has revealed two amino acid mutations that are associated with kdr and super-kdr resistance phenotypes. Both mutations are located in the domain II region of the channel; Leu1014 to Phe in the hydrophobic segment IIS6 and Met918 to Thr in the IIS4-IIS5 linker. To investigate… CONTINUE READING

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