Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells

  title={Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells},
  author={Yaroslav S. Kolesnikov and Kateryna Nokhrina and Sergii Kretynin and Igor D. Volotovski and Jan Martinec and Georgy A. Romanov and V. S. Kravets},
  journal={Biochemistry (Moscow)},
Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of phosphatidic acid, which often acts as secondary messenger of transduction of intracellular signals. This review summarizes data of leading laboratories on specific features of organization and regulation of PLD activity in plant and animal cells. The main structural domains of PLD (C2, PX, PH), the active site, and other functionally important parts of the enzyme are discussed. Regulatory mechanisms of PLD activity… 

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