Molecular structure of human lymphocyte receptor for immunoglobulin E.

  title={Molecular structure of human lymphocyte receptor for immunoglobulin E.},
  author={Hitoshi Kikutani and Seiji Inui and Ryuichiro Sato and E L Barsumian and Hisayuki Owaki and Kazuki Yamasaki and Tsuneyasu Kaisho and N Uchibayashi and Richard R Hardy and Toshihiko Hirano},
  volume={47 5},
We have isolated and sequenced a cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R). The deduced protein sequence reveals that Fc epsilon R consists of 321 amino acids, without any signal sequence, and is oriented with its N-terminus on the cytoplasmic side and its C-terminus on the outside of the cell. This molecule shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc epsilon R in endocytosis. Fc… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…