Molecular structure of human lymphocyte receptor for immunoglobulin E

  title={Molecular structure of human lymphocyte receptor for immunoglobulin E},
  author={H. Kikutani and S. Inui and R. Sato and E. Barsumian and T. Kishimoto},
  • H. Kikutani, S. Inui, +2 authors T. Kishimoto
  • Published 1986
  • Biology, Medicine
  • Cell
  • We have isolated and sequenced a cDNA clone encoding the human lymphocyte receptor for IgE (Fc epsilon R). The deduced protein sequence reveals that Fc epsilon R consists of 321 amino acids, without any signal sequence, and is oriented with its N-terminus on the cytoplasmic side and its C-terminus on the outside of the cell. This molecule shows striking sequence homology with chicken asialoglycoprotein receptor (hepatic lectin), suggesting a possible role for Fc epsilon R in endocytosis. Fc… CONTINUE READING
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