Molecular structure and assembly of the tight junction.

  title={Molecular structure and assembly of the tight junction.},
  author={Bradley M Denker and Sanjay K. Nigam},
  journal={The American journal of physiology},
  volume={274 1 Pt 2},
Polarized epithelial cells separate two extremely different cellular milieus. The tight junction (TJ) is the most apical component of the junctional complex and serves as the permeability barrier between these environments. The tight junctional complex appears to be a dynamic and regulated structure. Some of its protein components have been identified and include the transmembrane protein occludin. Nontransmembrane proteins on the cytosolic leaflet including ZO-1, ZO-2, cingulin, 7H6, and… CONTINUE READING