Molecular structure, phylogenetic analysis, tissue distribution, and function characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in sheep (Ovis aries).

@article{Ai2011MolecularSP,
  title={Molecular structure, phylogenetic analysis, tissue distribution, and function characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in sheep (Ovis aries).},
  author={Hong-xin Ai and Zhen-zhen Zhang and Yue-fen Shen and Jia-xin Zhang and Xu-ming Zhou and Cui Min and Shan-yuan Zhu and Shuang-quan Zhang},
  journal={Veterinary immunology and immunopathology},
  year={2011},
  volume={140 3-4},
  pages={329-34}
}
Interferon-γ-inducible-lysosomal thiol reductase (GILT) plays a key role in the processing and presentation of MHC class II-restricted antigen (Ag) by catalyzing disulfide bond reduction. In this study, a sheep cDNA, sGILT, encoding GILT protein was isolated from the spleen cDNA library of Ovis aries. It codes for a deduced protein of 244 amino acids with a putative molecular weight of 27.6 kDa, which has all the typical structural features of GILT protein including an active-site CXXC motif, a… CONTINUE READING