Molecular structural basis of ligand selectivity for 5-HT2 versus 5-HT1C cortical receptors

Abstract

A molecular structural criterion of ligand selectivity for the 5-HT2 versus 5-HT1C receptor was hypothesized on the basis of radioligand binding data. Despite the large number of compounds which have been tested at both receptors, analysis of published data led to the identification of only five agents which are greater than 10-fold selective for the 5-HT2… (More)
DOI: 10.1007/BF00167563

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