Molecular strategies to inhibit restenosis: modulation of the vascular myocyte phenotype.

@article{Walsh1996MolecularST,
  title={Molecular strategies to inhibit restenosis: modulation of the vascular myocyte phenotype.},
  author={Kenneth Walsh and Harris R Perlman},
  journal={Seminars in interventional cardiology : SIIC},
  year={1996},
  volume={1 3},
  pages={
          173-9
        }
}
The transduction of vascular myocytes with exogenous genetic material will be a common feature of many gene-based therapies for cardiovascular disorders. Therefore, the successful application of cardiovascular gene therapy will require a thorough understanding of the molecular biology of the smooth muscle cell. Of key importance are the transcriptional regulatory events that coordinate the de-differentiation and proliferation of myocytes in response to vascular injury. The goal of this review… CONTINUE READING

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