Molecular strategies in biological evolution of antimicrobial peptides.

@article{Nicolas2003MolecularSI,
  title={Molecular strategies in biological evolution of antimicrobial peptides.},
  author={Pierre Nicolas and Damien Vanhoye and Mohamed Amiche},
  journal={Peptides},
  year={2003},
  volume={24 11},
  pages={1669-80}
}
Gene-encoded antimicrobial peptides that protect the skin of hylid and ranin frogs against noxious microorganisms are processed from a unique family of precursor polypeptides with a unique pattern of conserved and variable regions opposite to that of conventional secreted peptides. Precursors belonging to this family, designated the preprodermaseptin, have a common N-terminal preproregion that is remarkably well conserved both within and between species, but a hypervariable C-terminal domain… CONTINUE READING