Molecular staging of lung cancer: real-time polymerase chain reaction estimation of lymph node micrometastatic tumor cell burden in stage I non-small cell lung cancer--preliminary results of Cancer and Leukemia Group B Trial 9761.

@article{Dcunha2002MolecularSO,
  title={Molecular staging of lung cancer: real-time polymerase chain reaction estimation of lymph node micrometastatic tumor cell burden in stage I non-small cell lung cancer--preliminary results of Cancer and Leukemia Group B Trial 9761.},
  author={J D'cunha and Angela L Corfits and James E. Herndon and Jeffrey A. Kern and Leslie J. Kohman and G. Alexander Patterson and Robert Arthur Kratzke and Michael Anthony Maddaus},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2002},
  volume={123 3},
  pages={484-91; discussion 491}
}
OBJECTIVE The 5-year survival for patients with surgically resected stage I non-small cell lung cancer is only 60% to 70%, probably because of undetected systemic occult micrometastases. Detection of occult micrometastases in lymph nodes by reverse-transcriptase polymerase chain reaction for carcinoembryonic antigen messenger RNA in non-small cell lung cancer has not been reported. Detection of occult micrometastases by standard reverse-transcriptase polymerase chain reaction provides only yes… CONTINUE READING

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