Molecular staging of cutaneous T-cell lymphoma: evidence for systemic involvement in early disease.

@article{Veelken1995MolecularSO,
  title={Molecular staging of cutaneous T-cell lymphoma: evidence for systemic involvement in early disease.},
  author={Hendrik Veelken and Gary Stewart Wood and Jessica Sklar},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={104 6},
  pages={889-94}
}
Biopsies of various tissues from eight patients with confirmed cutaneous T-cell lymphoma were analyzed for lymphomatous involvement using V-J junctional sequences in rearranged T-cell receptor-gamma genes as specific molecular markers for the malignant clone. The patients included one stage IA, one stage IB, and six stage IVA. Twenty-five specimens were analyzed including 14 skin, five lymph node, four blood, and two bone-marrow samples. Ten skin samples and four lymph node samples were… CONTINUE READING

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