Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern.

@article{AlShamsi2016MolecularSO,
  title={Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern.},
  author={Humaid Obaid Al-Shamsi and Jeremy Clifton Jones and Yazan Fahmawi and Ibrahim Dahbour and Aziz Tabash and R. R. Abdel-Wahab and Ahmed Abousamra and Kenna R. Mills Shaw and Lianchun Xiao and Manal Metwally Hassan and Benjamin R. Kipp and Scott Kopetz and Amr S Soliman and Robert R McWilliams and Robert A. Wolff},
  journal={Journal of gastrointestinal oncology},
  year={2016},
  volume={7 6},
  pages={
          882-902
        }
}
BACKGROUND The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in colorectal cancer (CRC) differ among populations. The aim of this study was to assess mutation frequencies in the Arab population and determine their correlations with certain clinicopathological features. METHODS Arab patients from the Arab Gulf region and a population of age- and sex-matched Western patients with CRC whose tumors were evaluated with next-generation sequencing (NGS) were identified and… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS