Molecular sorting in the secretory pathway.

@article{Chung1989MolecularSI,
  title={Molecular sorting in the secretory pathway.},
  author={Kyuhyuck Chung and Peter J. Walter and Gregory W. Aponte and Harvey A. Moore},
  journal={Science},
  year={1989},
  volume={243 4888},
  pages={192-7}
}
Proteins can be secreted from animal cells by either a constitutive or a regulated pathway; those destined for regulated secretion are actively sorted into dense-core secretory granules. Although sorting is generally assumed to be accomplished by specific carriers, the nature of these carriers remains elusive. In this study, peptide hormones were used as affinity ligands to purify a set of 25-kilodalton proteins from canine pancreatic tissue. Their ligand specificities and patterns of… CONTINUE READING

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