Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1.

@article{Madeja2003MolecularSO,
  title={Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1.},
  author={Michael Madeja and Thorsten Leicher and Patrick Friederich and Mark Andree Punke and Wilhelm Haverkamp and Ulrich Musshoff and G{\"u}nter Breithardt and Erwin-Josef Speckmann},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 3},
  pages={547-56}
}
The effects of the antiarrhythmic drug propafenone at Kv2.1 channels were studied with wild-type and mutated channels expressed in Xenopus laevis oocytes. Propafenone decreased the Kv2.1 currents in a time- and voltage-dependent manner (decrease of the time constants of current rise, increase of block with the duration of voltage steps starting from a block of less than 19%, increase of block with the amplitude of depolarization yielding a fractional electrical distance delta of 0.11 to 0.16… CONTINUE READING

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