Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity.

@article{Hemmrich2012MolecularSO,
  title={Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity.},
  author={Georg Hemmrich and Konstantin Khalturin and Anna-Marei Boehm and Malte Puchert and Friederike Anton-Erxleben and J{\"o}rg Wittlieb and Ulrich C. Klostermeier and Philip Rosenstiel and Hans-Heinrich Oberg and Tomislav Domazet-Lo{\vs}o and Toshimi Sugimoto and Hitoshi Niwa and Thomas C G Bosch},
  journal={Molecular biology and evolution},
  year={2012},
  volume={29 11},
  pages={3267-80}
}
How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage… CONTINUE READING
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