Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes

  title={Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes},
  author={Yichi Xu and Chunxuan Shao and Vadim B. Fedorov and Anna V. Goropashnaya and Brian M. Barnes and Jun Yan},
  booktitle={BMC Genomics},
Mammalian hibernators display phenotypes similar to physiological responses to calorie restriction and fasting, sleep, cold exposure, and ischemia-reperfusion in non-hibernating species. Whether biochemical changes evident during hibernation have parallels in non-hibernating systems on molecular and genetic levels is unclear. We identified the molecular signatures of torpor and arousal episodes during hibernation using a custom-designed microarray for the Arctic ground squirrel (Urocitellus… CONTINUE READING
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The hibernator metabolic phenotype is cardioprotective in the setting of deep hypothermic circulatory arrest [abstract]. Circulation 2011, 124:A17046

MV Podgoreanu, Q Ma, +7 authors BM Barnes
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