Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.

@article{Ciccarelli2007MolecularSM,
  title={Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.},
  author={Renata Ciccarelli and I D'alimonte and Patrizia Ballerini and Mariagrazia D'Auro and Eleonora Nargi and Silvana Buccella and Patrizia Di Iorio and Valeria Bruno and Ferdinando Nicoletti and Francesco Caciagli},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 5},
  pages={1369-80}
}
Astrocyte death may occur in neurodegenerative disorders and complicates the outcome of brain ischemia, a condition associated with high extracellular levels of adenosine and glutamate. We show that pharmacological activation of A(1) adenosine and mGlu3 metabotropic glutamate receptors with N(6)-chlorocyclopentyladenosine (CCPA) and (-)2-oxa-4-aminocyclo-[3.1.0]hexane-4,6-dicarboxylic acid (LY379268), respectively, protects cultured astrocytes against apoptosis induced by a 3-h exposure to… CONTINUE READING
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