Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells.

@article{Leonarduzzi2010MolecularSO,
  title={Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells.},
  author={Gabriella Leonarduzzi and Simona Gargiulo and Paola Gamba and Maria-Giulia Perrelli and Isabella Castellano and Anna Sapino and Barbara Sottero and Giuseppe Poli},
  journal={Molecular nutrition & food research},
  year={2010},
  volume={54 Suppl 1},
  pages={S31-41}
}
Oxidation of dietary cholesterol during food storage and processing, and/or that of endogenous cholesterol in the presence of increased steady-state levels of reactive oxygen species, leads to the production of derivatives, termed oxysterols. Among the biochemical effects exerted by an oxysterol mixture, it has recently been observed that marked up-regulation of CD36 scavenger receptor on macrophage cells plays a primary role in foam cell formation. This article reports evidence of a… CONTINUE READING

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