Molecular signaling mechanisms of renal gluconeogenesis in nondiabetic and diabetic conditions

  title={Molecular signaling mechanisms of renal gluconeogenesis in nondiabetic and diabetic conditions},
  author={Myat Theingi Swe and Anchalee Pongchaidecha and Varanuj Chatsudthipong and Nipon Chattipakorn and Anusorn Lungkaphin},
  journal={Journal of Cellular Physiology},
  pages={8134 - 8151}
The kidneys are as involved as the liver in gluconeogenesis which can significantly contribute to hyperglycemia in the diabetic condition. Substantial evidence has demonstrated the overexpression of rate‐limiting gluconeogenic enzymes, especially phosphoenolpyruvate carboxykinase and glucose 6 phosphatase, and the accelerated glucose release both in the isolated proximal tubular cells and in the kidneys of diabetic animal models and diabetic patients. The aim of this review is to provide an… Expand
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