Molecular signaling along the anterior–posterior axis of early palate development

  title={Molecular signaling along the anterior–posterior axis of early palate development},
  author={Tara M. Smith and Scott Lozanoff and Paul P. R. Iyyanar and Adil J. Nazarali},
  booktitle={Front. Physio.},
Cleft palate is a common congenital birth defect in humans. In mammals, the palatal tissue can be distinguished into anterior bony hard palate and posterior muscular soft palate that have specialized functions in occlusion, speech or swallowing. Regulation of palate development appears to be the result of distinct signaling and genetic networks in the anterior and posterior regions of the palate. Development and maintenance of expression of these region-specific genes is crucial for normal… CONTINUE READING
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Disruption of Fgf 10 / Fgfr 2 bcoordinated epithelialmesenchymal interactions causes cleft palate

  • R. Rice, B. Spencer-Dene, E. C. Connor, A. Gritli-Linde, A. P. McMahon, C. Dickson
  • J . Clin . Invest .
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