Molecular serotonergic mechanisms appear to mediate genetic sensitivity to cocaine-induced convulsions.

@article{ODell2000MolecularSM,
  title={Molecular serotonergic mechanisms appear to mediate genetic sensitivity to cocaine-induced convulsions.},
  author={Laura E O'Dell and Ren-de Li and Frank R. George and Mary C. Ritz},
  journal={Brain research},
  year={2000},
  volume={863 1-2},
  pages={213-24}
}
Cocaine-induced convulsions appear to be mediated by serotonin (5-HT) neurotransmission, acting primarily at 5-HT(2) receptors. However, this effect of cocaine is attenuated by cocaine binding at sigma and muscarinic M(1) and M(2) sites. This study examined whether the aforementioned neural sites mediate the nearly two-fold difference in sensitivity to cocaine-induced convulsions across C57BL/6J (6J) and C57BL/6ByJ (6ByJ) mice. Experiment 1 compared 5-HT transporter densities across several… CONTINUE READING

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