Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy.

@article{Elbein2004MolecularSO,
  title={Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy.},
  author={S. C. Elbein and Hailing Zheng and Yiwen Jia and Winston S. Chu and Judith J Cooper and Terri C Hale and Zhengxian Zhang},
  journal={Molecular genetics and metabolism},
  year={2004},
  volume={82 4},
  pages={321-8}
}
Increased glucose metabolism through the hexosamine pathway may result in insulin resistance, impaired insulin secretion, and diabetic nephropathy. We hypothesized that variants of GFPT1 encoding glutamine-fructose-6-phosphate amidotransferase, the rate limiting enzyme in this pathway, could increase GFPT1 gene expression and thus susceptibility to diabetes and diabetic nephropathy. To test this hypothesis, we screened for variation in the GFPT1 and flanking regions in Caucasian and African… CONTINUE READING